Search results for "evolution of antibiotic resistance"

showing 3 items of 3 documents

Conjugation is necessary for a bacterial plasmid to survive under protozoan predation

2016

Horizontal gene transfer by conjugative plasmids plays a critical role in the evolution of antibiotic resistance. Interactions between bacteria and other organisms can affect the persistence and spread of conjugative plasmids. Here we show that protozoan predation increased the persistence and spread of the antibiotic resistance plasmid RP4 in populations of the opportunist bacterial pathogenSerratia marcescens. A conjugation-defective mutant plasmid was unable to survive under predation, suggesting that conjugative transfer is required for plasmid persistence under the realistic condition of predation. These results indicate that multi-trophic interactions can affect the maintenance of con…

0106 biological sciences0301 basic medicineFood ChainMutant010603 evolutionary biology01 natural sciencesRP4 plasmidPredationMicrobiologyTetrahymena thermophila03 medical and health sciencesPlasmidAntibiotic resistanceevolution of antibiotic resistance/dk/atira/pure/subjectarea/asjc/1100PathogenSerratia marcescens/dk/atira/pure/subjectarea/asjc/1100/1101Evolutionary BiologybiologyAgricultural and Biological Sciences(all)Conjugationta1183ta1182biology.organism_classificationAgricultural and Biological Sciences (miscellaneous)Protozoan predation030104 developmental biologyprotozoan predationConjugation GeneticSerratia marcescensHorizontal gene transferta1181Evolution of antibiotic resistanceGeneral Agricultural and Biological SciencesBacteriaconjugationPlasmids
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Data from: Conjugation is necessary for a bacterial plasmid to survive under protozoan predation

2016

Horizontal gene transfer by conjugative plasmids plays a critical role in the evolution of antibiotic resistance. Interactions between bacteria and other organisms can affect the persistence and spread of conjugative plasmids. Here we show that protozoan predation increased the persistence and spread of the antibiotic resistance plasmid RP4 in populations of the opportunist bacterial pathogen Serratia marcescens. A conjugation-defective mutant plasmid was unable to survive under predation, suggesting that conjugative transfer is required for plasmid persistence under the realistic condition of predation. These results indicate that multi-trophic interactions can affect the maintenance of co…

medicine and health careprotozoan predationevolution of antibiotic resistanceLife SciencesMedicineRP4 plasmidSerratia marcescensconjugationTetrahymena thermophila
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Fight evolution with evolution: plasmid‐dependent phages with a wide host range prevent the spread of antibiotic resistance

2013

The emergence of pathogenic bacteria resistant to multiple antibiotics is a serious worldwide public health concern. Whenever antibiotics are applied, the genes encoding for antibiotic resistance are selected for within bacterial populations. This has led to the prevalence of conjugative plasmids that carry resistance genes and can transfer themselves between diverse bacterial groups. In this study, we investigated whether it is feasible to attempt to prevent the spread of antibiotic resistances with a lytic bacteriophage, which can replicate in a wide range of gram‐negative bacteria harbouring conjugative drug resistance–conferring plasmids. The counter‐selection against the plasmid was sh…

phage therapyPhage therapymedicine.drug_classmedicine.medical_treatmentAntibioticsta3111medicine.disease_causeMicrobiologyBacteriophageAntibiotic resistancePlasmidfaagiterapiaevolution of antibiotic resistanceGeneticsmedicineta318sairaalabakteerithospital bacteriaEcology Evolution Behavior and SystematicsGeneticsbiologyta1182Pathogenic bacteriaOriginal Articlesbiology.organism_classificationconjugative plasmid-dependent phagesantibioottivastustuskykyfagiterapiaHorizontal gene transferta1181General Agricultural and Biological SciencesBacteriaantibioottiresistenssiconjugationEvolutionary Applications
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